# Browse Dissertations - Biophysics and Computational Biology by Title

• (1970)

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• (2011-01-14)
Two-photon (2P) excited fluorescence microscopy is particularly advantageous for imaging biological specimens since it offers reduced scattering, deep sample penetration, and intrinsic confocality when excited with point ...

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• (1990)
The problem of protein dynamics is introduced and its significance explained. Properties of the oxygen-storage protein myoglobin (Mb) as a model system for dynamics studies are discussed. Special attention is paid to Mb's ...

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• (1970)

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• (1979)

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• (2015-01-21)
In eukaryotic cells, the genome is packed into fundamental units called nucleosomes, where 147 base pairs of DNA are wrapped around a protein core. Stable packing of DNA in nucleosomes imposes a barrier for accessibility ...

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• (1967)

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• (1958)

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• (1991)
Rhodopsin is the light-sensitive pigment of the photoreceptor cells of higher organisms. Photon absorption by rhodopsin initiates a biochemical amplification cascade that results in an electrical signal. Rhodopsin is ...

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• (1996)
Heme proteins are ubiquitous in biological systems and it is of interest to understand how the structure of various heme proteins determines their respective biological function. Using site-directed mutagenesis, the amino ...

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• (2010-05-14)
Translation, the process of reading genetic information and synthesizing the corresponding proteins, is universal and found throughout the three domains of life. The flow of information in translation involves a series of ...

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• (2014-01-16)
DNA helicases are motor enzymes that convert the chemical energy of nucleotide triphosphate hydrolysis into mechanical energy for translocation on single stranded (ss) DNA and unwinding of double stranded (ds) DNA. All ...

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• (2014-01-16)
Retinoic acid-inducible gene 1 (RIG-I) plays a major role in antiviral innate immunity by detecting cytoplasmic viral RNA and triggering the pathway that leads to transcriptional activation of type I interferon (IFN). Type ...

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• (2012-02-01)
A DNA helicase, PcrA is an essential protein in gram-positive bacteria. PcrA utilizes its helicase activity and translocation activity to regulate various cellular functions including plasmid replication and counteracting ...

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• (1994)
Unusual DNA sequences are known to adopt interesting three-dimensional structures which might have important biological roles. For my thesis, I have tried to study the influence of various degrees of perturbations of DNA ...

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• (1965)

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• (1994)
The similarity between spin glasses and proteins is that both have complex energy landscapes with multiple energy minima and barriers. The approach to equilibrium in such systems has been previously studied. We present ...

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• (1991)
The structure of reaction centers (RCs) was modified with various sulfhydryl reagents. It was found that mercurial reagents, especially p-chloromercuribenzenesulfate (pCMBS), inhibit Q$\sb{\rm B}$ function in RCs from ...

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• (2013-02-03)
Biological chemistry revolves around the abiogenetic interplay of high energy labile chemical linkages which shuttle energy and chemical potential, and stable and degradation resistant bonds that make up the biological ...

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• (2009)
Membrane proteins constitute more than half of all drug targets in the pharmaceutical industry today, which is not surprising given that a third of human genome codes for membrane proteins, and that they perform a large ...

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