# Browse Dissertations - Biophysics and Computational Biology by Title

• (2010-05-14)
Translation, the process of reading genetic information and synthesizing the corresponding proteins, is universal and found throughout the three domains of life. The flow of information in translation involves a series of ...

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• (2014-01-16)
DNA helicases are motor enzymes that convert the chemical energy of nucleotide triphosphate hydrolysis into mechanical energy for translocation on single stranded (ss) DNA and unwinding of double stranded (ds) DNA. All ...

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• (2014-01-16)
Retinoic acid-inducible gene 1 (RIG-I) plays a major role in antiviral innate immunity by detecting cytoplasmic viral RNA and triggering the pathway that leads to transcriptional activation of type I interferon (IFN). Type ...

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• (2012-02-01)
A DNA helicase, PcrA is an essential protein in gram-positive bacteria. PcrA utilizes its helicase activity and translocation activity to regulate various cellular functions including plasmid replication and counteracting ...

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• (1994)
Unusual DNA sequences are known to adopt interesting three-dimensional structures which might have important biological roles. For my thesis, I have tried to study the influence of various degrees of perturbations of DNA ...

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• (1965)

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• (1994)
The similarity between spin glasses and proteins is that both have complex energy landscapes with multiple energy minima and barriers. The approach to equilibrium in such systems has been previously studied. We present ...

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• (1991)
The structure of reaction centers (RCs) was modified with various sulfhydryl reagents. It was found that mercurial reagents, especially p-chloromercuribenzenesulfate (pCMBS), inhibit Q$\sb{\rm B}$ function in RCs from ...

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• (2013-02-03)
Biological chemistry revolves around the abiogenetic interplay of high energy labile chemical linkages which shuttle energy and chemical potential, and stable and degradation resistant bonds that make up the biological ...

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• (2009)
Membrane proteins constitute more than half of all drug targets in the pharmaceutical industry today, which is not surprising given that a third of human genome codes for membrane proteins, and that they perform a large ...

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• (1996)
Antibody molecules are highly antigen-specific receptors of the immune system. In this thesis, structural and functional relationship in antibody molecules are studied.

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• (2008)
High-density lipoproteins (HDL) are protein-lipid particles that are involved in the transport of cholesterol in the blood. They are of great importance in the treatment of coronary heart disease as low levels of HDLs are ...

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• (2012-06-27)
In my thesis, I have focused on new methodology development combined with state-of-the-art solid-state nuclear magnetic resonance (NMR) experiments with scanning transmission electron microscopy (STEM) to obtain atomic ...

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• (2013-02-03)
IspG, farnesyl diphosphate synthase (FPPS) and geranylgeranyl diphosphate synthase (GGPPS) are enzymes involved in isoprenoid biosynthesis. Most bacterial IspGs contain two domains: a TIM barrel (A) and a 4Fe4S domain (B), ...

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• (2010-05-14)
Cytochrome c oxidase is the terminal enzyme to accept electrons from cytochrome c in the respiratory chain of mitochondria, bacteria and archaea. It couples the reducing oxygen to water and pumping the protons across the ...

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• (2010-01-06)
This work deals with three important problems in membrane protein folding studies, namely the preparation and storage of homogeneous small unilamellar vesicles (SUV), the development of an algorithm for selecting soluble ...

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• (2009)
This work deals with three important problems in membrane protein folding studies, namely the preparation and storage of homogeneous small unilamellar vesicles (SUV), the development of an algorithm for selecting soluble ...

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• (2010-01-06)
Aerobic organisms derive energy needed to sustain life from foodstuffs through the process of cellular respiration. Respiration is performed by a series of soluble and multi-subunit membrane proteins that form the ...

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• (1989)
I. Three kinds of monoclonal antibodies have been found against iodopsin and other cone pigments in chicken retina: (1) specifically against iodopsin (cell line of 7D3); (2) against iodopsin and another cone pigment (cell ...

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• (1985)
Cation Binding By Bacteriorhodopsin (bR). bR normally has a purple color ((lamda)(,max) = 558 nm), hence the name, purple membrane. Atomic absorption spectrophotometry shows that purple membrane binds approximately 4 Ca('++) ...

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