# Browse Dissertations - Biophysics and Computational Biology by Title

• (2010)
Finally, ongoing work is presented on the role of ribosomal signatures in the first steps of ribosomal assembly. Ribosomal signatures are features that are completely conserved within one domain of life but absent from the ...

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• (2010-05-14)
Translation, the process of reading genetic information and synthesizing the corresponding proteins, is universal and found throughout the three domains of life. The flow of information in translation involves a series of ...

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• (2006)
DNA replication is a complex process involving many proteins that must be performed for a cell to proliferate. In this work, we will study three members of the replication system: single-stranded DNA, single-stranded DNA ...

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• (2014-01-16)
DNA helicases are motor enzymes that convert the chemical energy of nucleotide triphosphate hydrolysis into mechanical energy for translocation on single stranded (ss) DNA and unwinding of double stranded (ds) DNA. All ...

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• (2014-01-16)
Retinoic acid-inducible gene 1 (RIG-I) plays a major role in antiviral innate immunity by detecting cytoplasmic viral RNA and triggering the pathway that leads to transcriptional activation of type I interferon (IFN). Type ...

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• (2012-02-01)
A DNA helicase, PcrA is an essential protein in gram-positive bacteria. PcrA utilizes its helicase activity and translocation activity to regulate various cellular functions including plasmid replication and counteracting ...

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• (1994)
Unusual DNA sequences are known to adopt interesting three-dimensional structures which might have important biological roles. For my thesis, I have tried to study the influence of various degrees of perturbations of DNA ...

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• (1965)

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• (2005)
The Rieske iron-sulfur protein (ISP) subunit of Rhodobacter sphaeroides cytochrome bc1 complex was isolated and then investigated using molecular spectroscopies (high-resolution electron paramagnetic resonance and resonance ...

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• (1994)
The similarity between spin glasses and proteins is that both have complex energy landscapes with multiple energy minima and barriers. The approach to equilibrium in such systems has been previously studied. We present ...

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• (2006)
The lantibiotic nisin is a 34-residue bacteriocin produced by the Gram-positive bacteria Lactococcus lactis spp. It is first ribosomally synthesized as an inactive precursor which is then post-translationally modified into ...

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• (1991)
The structure of reaction centers (RCs) was modified with various sulfhydryl reagents. It was found that mercurial reagents, especially p-chloromercuribenzenesulfate (pCMBS), inhibit Q$\sb{\rm B}$ function in RCs from ...

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• (2005)
This study explores the behaviour of adhesive complexes of cell adhesion molecules undergoing forced detachment. Molecular-forces measurements combined with Steered Molecular Dynamic (SMD) simulations were used to investigate ...

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• (1999)
An HMG box is a DNA binding domain common to a large number of proteins whose diversity in function range from transcriptional activation and repression to chromatin assembly. These proteins can be viewed as two classes ...

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• (2013-02-03)
Biological chemistry revolves around the abiogenetic interplay of high energy labile chemical linkages which shuttle energy and chemical potential, and stable and degradation resistant bonds that make up the biological ...

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• (2009)
Membrane proteins constitute more than half of all drug targets in the pharmaceutical industry today, which is not surprising given that a third of human genome codes for membrane proteins, and that they perform a large ...

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• (2001)
On the other hand, ssDNA-protein interaction is far less well understood than dsDNA-protein interactions. Gene V proteins from the filamentous phages are excellent systems for studying the interactions between protein and ...

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• (1996)
Antibody molecules are highly antigen-specific receptors of the immune system. In this thesis, structural and functional relationship in antibody molecules are studied.

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• (2002)
Lastly, I present preliminary results on the development of a new technique called two-color FRET-FCS (a combination of Fluorescence Resonance Energy Transfer and Fluorescence Correlation Spectroscopy) and its application ...

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• (2008)
High-density lipoproteins (HDL) are protein-lipid particles that are involved in the transport of cholesterol in the blood. They are of great importance in the treatment of coronary heart disease as low levels of HDLs are ...

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