Browse Dissertations - Biophysics and Computational Biology by Title

• (1994)
In biological systems, DNA/RNA-protein interactions as well as drug-DNA interactions play important roles in genetic processes. A fundamental understanding of these processes requires a detailed structural knowledge of ...

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• (1975)

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• (1992)
We have analyzed the behavior of a linear, cyclic, four state model of regulation of contraction of smooth muscle. The model involves twenty one parameters: sixteen rate constants, three initial conditions, and NT$\sb3$ ...

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• (2013-05-28)
Myotonic dystrophy type 1 (DM1) is caused by an expanded CUG repeat (CUGexp) that sequesters muscleblind-like 1 protein (MBNL1), a protein that regulates alternative splicing. CUGexp RNA is a validated drug target for this ...

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• (1991)
Low intensity ultrasound (approximately 10$\sp{-6}$ W/cm$\sp2$) in the frequency range of 0.5 MHz to 5.0 MHz was employed to investigate biomembrane structural relaxation kinetics via absorption and velocity dispersion ...

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• (2009)
Experimental methods in biology are generally able to provide low-resolution data on specific functions of biomolecules, or high-resolution data on structures and other properties in states of questionable physiological ...

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• (2014-05-30)
Over the last several years, microfluidic-based techniques have been developed to study inducible gene expression at the single cell level, albeit without the ability to control external stimuli with precise methods. Most ...

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• (2011-05-25)
The folding of interphase chromatin into large-scale chromatin structure and its spatial organization within nucleus has been suggested to have important roles in gene regulation. In this study, we created engineered ...

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• (2011-05-25)
The bacteria Rhodobacter sphaeroides uses photosynthetic reaction centers to convert light into chemical energy. Light absorption by the reaction center results in electron transfer through a series of cofactors, the ...

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• (1995)
Magnetic resonance (MR) is a rapidly growing versatile and non-destructive tool for investigation of various aspects of biochemistry, physiology and disease. It is valuable to evaluate the new MR techniques and apply them ...

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• (1989)
Bacterium Rhodopseudomonas viridis has four c-type cytochromes integrated to a single protein subunit of the reaction center complex. Two of them are high redox midpoint potential hemes (cyt-c559; Em = 380 mV and cyt-c556; ...

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• (1991)
This thesis is a report of cation effects on the purple membrane of Halobacterium halobium. Included are proton and divalent cation studies using purple, blue, and pink membranes and the apoprotein. The blue species of ...

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• (1993)
Guinea pig left atria were suspended in a tissue bath of normal Krebs-Henseleit solution which was aerated with 95% O$\sb2$/5% CO$\sb2$ and maintained at 27$\sp\circ$C. The atria were attached to a force transducer and ...

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• (1983)
The contractile strength of heart muscle is strongly dependent on the rate of beating, and on the pattern of previous contractions over a period of many seconds. The activator calcium ions, which are responsible for the ...

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• (1990)
The ability of myofilament space calcium to modulate the sarcoplasmic reticulum (s.r.) calcium release channel in skeletal muscle was investigated. Two different experimental techniques were used to study this phenomenon. ...

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• (1964)

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• (1994)
Cone visual pigments are responsible for color vision. Although a large amount is known about rod pigments, relatively little is known about cone pigments. This thesis describes the identification and characterization of ...

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• (1968)

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• (1972)

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• (1983)
The three themes of the thesis are: (1) the search for light-activated enzymes in octopus photoreceptors analogous to those found in vertebrates' photoreceptors, (2) the question of which photointermediate(s) of photoexcited ...

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