Dept. of Cell and Developmental Biology
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(2015-01-21)Molecular chaperones have evolved to support the general stability and maintenance of the cellular proteome. Through their broad binding capacity, transient interactions, and high cellular abundance, the Hsp70 and Hsp90 ...
(2015-01-21)The mammalian cell nucleus is a complex yet highly organized structure. There is significant amount of knowledge about the organization of nucleus; however, the influence of such structural complexity of the nucleus in ...
(2015-01-21)Cellular and developmental processes are regulated by extracellular and intracellular signals that are mediated by networks of signaling pathways. In recent years, microRNAs have also emerged as a class of critical modulators ...
(2015-01-21)Much remains to be understood regarding the molecular mechanisms controlling stem cell fate. Through studies in human pluripotent stem cells (hPSCs), I have identified SGK196, an atypical kinase of relatively unknown ...
A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression (2009)The classical genomic pathway for 17beta-estradiol (E 2) action involves binding to estrogen receptor alpha (ERalpha) in target cells, interaction with estrogen response element (ERE)-containing DNA, recruitment of ...