Dept. of Microbiology
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Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein (2008)Using a series of MC160 deletion mutant proteins, we found that two distinct regions of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 ...
(2015-07-15)Natural products continue to be an important source of therapeutically-relevant compounds. With the advent of inexpensive genome sequencing it has become apparent that bacteria produce a larger array of natural products ...
The iron-dependent cyanide and hydrogen peroxide co-toxicity in Escherichia coli and its catastrophic consequences for the chromosome (2015-06-22)Hydrogen peroxide (H2O2) can oxidize cytoplasmic ferrous ions (Fe2+) to produce highly reactive hydroxyl radicals (•OH) via Fenton’s reaction that can damage various biomolecules causing oxidative stress. Even though at ...
Building a Consistent Neuronetwork: Defining Molecular Cues Involved in the Synaptic Target Recognition of Drosophila Melanogaster (2001)Every synaptogenesis begins with "synaptic target recognition", a cell-cell recognition event in which a neuron and its target stably adhere. Herein I describe two transmembrane molecules present on a subset of muscles in ...
Reengineering Estrogen Receptor Hormone Specificity Through Coordinated Changes at Key Contact Sites Between Estrogen Receptor and Estradiol (2001)The specificity of hormone action arises principally from the specific interaction that a hormonal ligand has with its cognate receptor. This interaction is defined by steric and electronic complementarity at certain sites ...