Dept. of Microbiology
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Structure and function analysis of the natural product plantazolicin, a bacillus anthracis-specific antibiotic (2015-11-30)Bacteria are a fruitful source of metabolites, many of which have been the scaffolds for the majority of approved antibiotic compounds. In this dissertation, I present the discovery and characterization of a bacterial ...
Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein (2008)Using a series of MC160 deletion mutant proteins, we found that two distinct regions of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 ...
(2015-07-15)Natural products continue to be an important source of therapeutically-relevant compounds. With the advent of inexpensive genome sequencing it has become apparent that bacteria produce a larger array of natural products ...
The iron-dependent cyanide and hydrogen peroxide co-toxicity in Escherichia coli and its catastrophic consequences for the chromosome (2015-06-22)Hydrogen peroxide (H2O2) can oxidize cytoplasmic ferrous ions (Fe2+) to produce highly reactive hydroxyl radicals (•OH) via Fenton’s reaction that can damage various biomolecules causing oxidative stress. Even though at ...
Building a Consistent Neuronetwork: Defining Molecular Cues Involved in the Synaptic Target Recognition of Drosophila Melanogaster (2001)Every synaptogenesis begins with "synaptic target recognition", a cell-cell recognition event in which a neuron and its target stably adhere. Herein I describe two transmembrane molecules present on a subset of muscles in ...