Dept. of Microbiology
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Identification and characterization of thiamine biosynthesis, transport, and regulation elements among bacteroides species (2018-07-27)Thiamine (vitamin B1) is an essential cofactor for all organisms. Humans primarily acquire thiamine through their diet and thiamine deficiencies have adverse neurological effects. However, the role gut microbes play in ...
(2018-10-08)Methane producing archaea have a vital role in the global carbon cycle by facilitating the conversion of organic carbon into CO2 and methane. Species of Methanosarcina are unique among methanogens due to a versatile ...
Escape to the interior: Characterization of the cytosolic delivery of C-terminal cargo subdomains by the N-terminus of pasteurella multocida toxin and subsequent toxin-mediated downregulation of Gaq-PLCb1 signaling through depletion of Gaq from the plasma membrane (2018-07-27)The bacterium Pasteurella multocida is a gram-negative, non-spore- forming, capsulated coccobacillus that lives an aerobic to facultative anaerobic lifestyle. P. multocida is a zoonotic pathogen that causes a myriad of ...
(2018-06-08)Microorganisms are an invaluable source of natural products. As humans, we have taken advantage of these small molecules to improve overall human health and quality of life. However, the rise in the number of pathogens ...
Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity (2018-04-19)Vaccinia virus (VACV) is a master manipulator of the immune response, and is also a prime candidate for vaccine vectors. This thesis explored both properties through (i) identification and characterization of the VACV M1 ...