The acc locus from the classic nopaline-type Ti plasmid pTiC58 confers utilization of agrocinopines A+B and susceptibility to an antibiotic called agrocin 84. DNA sequence analyses revealed that acc is composed of eight ...

The genetic code has evolved with considerable elasticity, enabling most amino acids to be encoded by multiple synonymous codons. Genes can vary in their utilization of synonymous codons, and this provides a basis of ...

The aim of this thesis is to further define the entry and trafficking pathways of the dermonecrotic toxin family composed of related AB toxins whose members induce dermonecrosis upon injection into animal skin. The ...

Conjugation assays determined that the bacteria mate in a cell density dependent manner, known as quorum-sensing. Analysis of transfer frequencies using a transfer-constitutive mutant of pTiC58 showed that quorum sensing ...

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that is capable of causing systemic infection in mammals. Its normal course of infection brings this organism into the diverse environments ...

Large, low copy number plasmids, such as those harboring antibiotic resistance genes, often possess plasmid maintenance systems to ensure their persistence and inheritance in a bacterial population. One example is the ...

Salmonella enterica serovar Typhimurium injects a set of effector proteins into the host cell cytoplasm via the Salmonella Pathogenicity Island I (SPI1) type III secretion system (T3SS) to induce inflammatory diarrhea and ...

The covalent attachment of lipoic acid to the lipoyl domains (LDs) of the central metabolism enzymes pyruvate dehydrogenase (PDH) and oxoglutarate dehydrogenase (OGDH) is essential for their activation and thus for respiratory ...