Dept. of Molecular and Integrative Physiology
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Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors (2015-01-21)The broad, long-term objective of this research is to develop drug leads for new antibiotics, antiparasitics, and cancer chemotherapeutics. Two main areas of focus are inhibition of the Methyl Erythritol Phosphate (MEP; ...
(2015-01-21)The sequenced genetic codes for multiple species have provided great sources for understanding how a single genome can give rise to a complex organism. However, only a small percent of mammalian genome could be identified ...
Reciprocal interactions between feeding and turning motor networks mediate foraging decisions in a predatory sea-slug (2015-01-21)All animals constantly select among an array of competing behaviors in response to environmental stimuli and internal state to maximize their fitness. In simpler invertebrate nervous systems, decision-making arises at the ...
Dielectric Relaxation Processes at Apical Membranes of Frog Skin: Changes of Capacitance and Sodium Ion Channel Density (1993)Impedance measurements were carried out on isolated epithelia of frog skin, to characterize the capacitive properties of their apical plasma membranes and to determine whether vesicle fusion is the likely mechanism for the ...
Identification and Characterization of Transcriptional Regulatory Elements for Liver-Specific Expression of Rabbit CYP2C Genes (1993)Heme-containing monooxygenases cytochrome P450 are involved in the oxidative metabolism of many xenobiotic substances and endogenous compounds. These enzymes are encoded by a superfamily of CYP genes, among which mammalian ...