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Joint estimation of water and fat images from magnetic resonance signals

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Title: Joint estimation of water and fat images from magnetic resonance signals
Author(s): Hernando, Diego
Director of Research: Liang, Zhi-Pei
Doctoral Committee Chair(s): Liang, Zhi-Pei
Doctoral Committee Member(s): Boppart, Stephen A.; Bresler, Yoram; Sutton, Bradley P.
Department / Program: Electrical & Computer Eng
Discipline: Electrical & Computer Engr
Degree Granting Institution: University of Illinois at Urbana-Champaign
Degree: Ph.D.
Genre: Dissertation
Subject(s): Magnetic Resonance Imaging (MRI) Joint estimation Fat-water Graph cuts Regularization Fat quantification
Abstract: Fat-water separation is a classical problem for in vivo magnetic resonance imaging, with multiple applications both in cases where the aim is the removal of fat signal, as well as in cases where the fat signal itself is of diagnostic interest. Although many methods have been proposed, robust fat-water separation remains a challenge. The problem presents two key difficulties: (a) the presence of B0 field inhomogeneities, which makes the problem non-linear and ill-posed; and (b) the difficulty of accurately modeling the acquired signal, which can lead to bias in quantitative fat-water separation applications. The research in this thesis has developed joint estimation methods to address the ill-posedness of the problem by simultaneously estimating the complete fat-water images and field inhomogeneity map. The joint estimation formulation developed in this work is able to overcome the complications of voxel-by-voxel separation, and it allows characterization of the resolution properties of its estimates, but results in a challenging optimization problem. To address this complication, optimization algorithms based on graph cuts have been developed and studied. Additionally, this work addresses the modeling issues of fat-water separation by comparing a set of recently proposed models, demonstrating that accurate spectral modeling of the acquired signal is critical for quantitative applications. Simulation, phantom and in vivo results are included to highlight the properties of the proposed methods and compare them to previous approaches. This thesis also contains example applications of the proposed methods, with an emphasis on the characterization of intramyocardial fat.
Issue Date: 2010-08-20
URI: http://hdl.handle.net/2142/16833
Rights Information: Copyright 2010 Diego Hernando
Date Available in IDEALS: 2010-08-20
Date Deposited: 2010-08
 

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