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Title:Catheter for endoscopic magnetomotive optical coherence tomography
Author(s):Li, Di
Advisor(s):Boppart, Stephen A.
Department / Program:Nuclear, Plasma, & Rad Engr
Discipline:Nuclear Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:M.S.
Genre:Thesis
Subject(s):Optical Coherence Tomography
Catheter
Magnetomotive optical coherence tomography (OCT)
Abstract:In this thesis, a catheter design is proposed for endoscopic magnetomotive optical coherence tomography (MM-OCT). Magnetomotive optical coherence tomography is a novel technique which uses targeted magnetic contrast agents for contrast enhancement of OCT imaging. In MM-OCT, microspheres and magnetic nanoparticles (MNPs) are introduced into tissue and an electromagnet is used to generate a small modulated magnetic field within the tissue during OCT imaging. The magnetic field will introduce mechanical displacement of the MNPs, which can be detected, and the MM-OCT signal can be measured. The current bench-top set-up does not allow for in vivo MM-OCT imaging because the magnetic field is provide by a solenoid with an outer diameter of ~18 mm and an axial thickness of ~9 mm. A magnetomotive catheter design was developed by wrapping small coil around the distal end of a standard OCT catheter to combine the novel MM-OCT technology and catheter-based OCT. The coil has a small size while providing a local magnetic field for MM-OCT imaging. This magnetomotive catheter will enable investigations of in vivo magnetomotive contrast enhancement from the magnetic agents used in MM-OCT imaging.
Issue Date:2011-01-21
URI:http://hdl.handle.net/2142/18621
Rights Information:Copyright 2010 Di Li
Date Available in IDEALS:2011-01-21
2013-01-22
Date Deposited:2010-12


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