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Title:Effects of in vivo dexamethasone sodium phosphate on in vitro equine neutrophil function
Author(s):Sturtevant, Faye Coleman
Department / Program:Veterinary Medicine - Pathobiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Agriculture, Animal Pathology
Abstract:Neutrophil function was evaluated in vitro 24 and 48 hours after administration of a single IV dose of dexamethasone sodium phosphate (0.088 mg/kg) to adult horses. Neutrophils were separated from whole blood using a two-step Percoll gradient. Purified neutrophils from dexamethasone-treated horses had impaired ability to kill Staphylococcus aureus as compared to pretreatment and normal horse neutrophils. Neither phagocytosis, iodination, or phagosome-lysosome fusion was affected by treatment. Hydrogen peroxide production, measured both spectrophotometrically and by flow cytometry, was not affected by treatment. Lysosomal enzyme activity for alkaline phosphatase, acid phosphatase, lysozyme, $\beta$-glucuronidase, and myeloperoxidase was quantitated and was not affected by treatment.
Issue Date:1989
Rights Information:Copyright 1989 Sturtevant, Faye Coleman
Date Available in IDEALS:2011-05-07
Identifier in Online Catalog:AAI9011040
OCLC Identifier:(UMI)AAI9011040

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