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Effects of in vivo dexamethasone sodium phosphate on in vitro equine neutrophil function

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Title: Effects of in vivo dexamethasone sodium phosphate on in vitro equine neutrophil function
Author(s): Sturtevant, Faye Coleman
Department / Program: Veterinary Medicine - Pathobiology
Discipline: Pathobiology
Degree Granting Institution: University of Illinois at Urbana-Champaign
Degree: Ph.D.
Genre: Dissertation
Subject(s): Agriculture, Animal Pathology
Abstract: Neutrophil function was evaluated in vitro 24 and 48 hours after administration of a single IV dose of dexamethasone sodium phosphate (0.088 mg/kg) to adult horses. Neutrophils were separated from whole blood using a two-step Percoll gradient. Purified neutrophils from dexamethasone-treated horses had impaired ability to kill Staphylococcus aureus as compared to pretreatment and normal horse neutrophils. Neither phagocytosis, iodination, or phagosome-lysosome fusion was affected by treatment. Hydrogen peroxide production, measured both spectrophotometrically and by flow cytometry, was not affected by treatment. Lysosomal enzyme activity for alkaline phosphatase, acid phosphatase, lysozyme, $\beta$-glucuronidase, and myeloperoxidase was quantitated and was not affected by treatment.
Issue Date: 1989
Type: Text
Language: English
URI: http://hdl.handle.net/2142/19795
Rights Information: Copyright 1989 Sturtevant, Faye Coleman
Date Available in IDEALS: 2011-05-07
Identifier in Online Catalog: AAI9011040
OCLC Identifier: (UMI)AAI9011040
 

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