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Title:Design and utilization of chiral selectors for enantioselective membrane transport
Author(s):Bowen, William Edwin
Doctoral Committee Chair(s):Pirkle, William H.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, General
Chemistry, Analytical
Chemistry, Organic
Abstract:Systematic investigations of chiral recognition mechanisms have led to chiral selectors which, when immobilized and used as chromatographic stationary phases, show high levels of enantioselectivity. Since these selectors are designed to function in essentially the same manner whether immobilized or in solution, the chromatographic data enable one to quickly evaluate the suitability of a selector for use in hollow-fiber membrane systems. Several chromatographically developed selectors show promise for large scale separation of enantiomers using hollow-fiber membrane technology. Chiral selectors derived from N-(1-naphthyl)leucine have been used in a hollow-fiber membrane system (Sepracor) to separate the enantiomers of amino acid derivatives. Enantiomeric purities exceeding 95% have been obtained in a single pass through the system. For data collection, sample sizes were limited to gram quantities of racemate. However, it is clear that the present system could be used to resolve larger samples and that the continuous (as opposed to batch) process scale separation of enantiomers is feasible by this approach.
Issue Date:1994
Type:Text
Language:English
URI:http://hdl.handle.net/2142/20831
Rights Information:Copyright 1994 Bowen, William Edwin
Date Available in IDEALS:2011-05-07
Identifier in Online Catalog:AAI9503146
OCLC Identifier:(UMI)AAI9503146


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