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Title:Effects of acute and chronic exercise on the activities of hepatic lipogenic enzymes in rats
Author(s):Griffiths, Margaret A.
Doctoral Committee Chair(s):Boileau, Richard A.
Department / Program:Kinesiology and Community Health
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Health Sciences, Nutrition
Abstract:Effects of acute exercise and chronic exercise training on activities of five hepatic lipogenic enzymes were studied in rats fed different high-carbohydrate diets. In Study 1, ATP citrate lyase (CL), pyruvate kinase (PK), and fatty acid synthase (FAS) activities were greater in rats fed a high-fructose diet than in rats fed high-glucose or high-cornstarch diets. Exercise decreased CL, PK, FAS, and glucose-6-phosphate dehydrogenase (G6PDH) activities, especially in fructose-fed rats. Study 2 examined the time course of dietary induction of enzymes in fasted/refed rats, and the inhibitory effect of exhaustive exercise on induction. Fasting suppressed all activities to minimal levels. FAS and PK activities increased between 4 and 8 hours of refeeding, then plateaued and were greater in fructose versus cornstarch rats. Activities of malic enzyme, CL, and G6PDH peaked after 48 hours; fructose-fed rats had higher activities than cornstarch-fed rats. Exercise inhibited activities of FAS, PK, and G6PDH, especially in fructose-fed rats. Study 3 investigated whether chronic exercise training would prevent dietary-induction of FAS and PK. Activities of all enzymes were two times greater in fructose-fed versus cornstarch-fed rats. Cornstarch-fed rats showed significantly lower FAS activity with training; fructose-fed rats had significantly lower PK activity after training.
Issue Date:1994
Rights Information:Copyright 1994 Griffiths, Margaret A.
Date Available in IDEALS:2011-05-07
Identifier in Online Catalog:AAI9512376
OCLC Identifier:(UMI)AAI9512376

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