Title: | Effects of acute and chronic exercise on the activities of hepatic lipogenic enzymes in rats |
Author(s): | Griffiths, Margaret A. |
Doctoral Committee Chair(s): | Boileau, Richard A. |
Department / Program: | Kinesiology and Community Health |
Discipline: | Kinesiology |
Degree Granting Institution: | University of Illinois at Urbana-Champaign |
Degree: | Ph.D. |
Genre: | Dissertation |
Subject(s): | Health Sciences, Nutrition |
Abstract: | Effects of acute exercise and chronic exercise training on activities of five hepatic lipogenic enzymes were studied in rats fed different high-carbohydrate diets. In Study 1, ATP citrate lyase (CL), pyruvate kinase (PK), and fatty acid synthase (FAS) activities were greater in rats fed a high-fructose diet than in rats fed high-glucose or high-cornstarch diets. Exercise decreased CL, PK, FAS, and glucose-6-phosphate dehydrogenase (G6PDH) activities, especially in fructose-fed rats. Study 2 examined the time course of dietary induction of enzymes in fasted/refed rats, and the inhibitory effect of exhaustive exercise on induction. Fasting suppressed all activities to minimal levels. FAS and PK activities increased between 4 and 8 hours of refeeding, then plateaued and were greater in fructose versus cornstarch rats. Activities of malic enzyme, CL, and G6PDH peaked after 48 hours; fructose-fed rats had higher activities than cornstarch-fed rats. Exercise inhibited activities of FAS, PK, and G6PDH, especially in fructose-fed rats. Study 3 investigated whether chronic exercise training would prevent dietary-induction of FAS and PK. Activities of all enzymes were two times greater in fructose-fed versus cornstarch-fed rats. Cornstarch-fed rats showed significantly lower FAS activity with training; fructose-fed rats had significantly lower PK activity after training. |
Issue Date: | 1994 |
Type: | Text |
Language: | English |
URI: | http://hdl.handle.net/2142/21476 |
Rights Information: | Copyright 1994 Griffiths, Margaret A. |
Date Available in IDEALS: | 2011-05-07 |
Identifier in Online Catalog: | AAI9512376 |
OCLC Identifier: | (UMI)AAI9512376 |