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Title:Influence of ambient temperature on sleep, body temperature, and thermoregulation after phentolamine in rats
Author(s):Kent, Stephen Patric Terrance
Doctoral Committee Chair(s):Satinoff, Evelyn
Department / Program:Psychology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biology, Neuroscience
Psychology, Psychobiology
Abstract:The monoaminergic theory of sleep proposed that norepinephrine is responsible for the maintenance of rapid-eye-movement sleep (REMS). This theory is partially based on decreases in REMS after administration of noradrenergic antagonists. However, a reduction in REMS may not necessarily be due to a drug's effects on basic sleep mechanisms. Most noradrenergic agents, including all those that have been used in sleep studies, also affect body temperature (Tb). The effects of thermal stress on sleep, especially REMS, are large. Phentolamine (PHEN), a nonselective $\alpha$-adrenoceptor antagonist, both decreases REMS and causes a dose and ambient temperature (Ta)-dependent drop in Tb. This dissertation contains 3 experiments, the first of which examined the correlation between changes in Tb and sleep after PHEN at various Ta's. Changes in sleep were highly correlated with changes in Tb: when Tb dropped, amounts of sleep, especially REMS, also were decreased. When Tb did not change, sleep was unaffected. The second and third experiments sought to determine whether PHEN lowered Tb by acting on the thermal set-point or by altering one or more thermoregulatory effectors. The second experiment utilized operant thermoregulation to determine the range of preferred Ta's post-PHEN. The results show that decreases in Tb post-PHEN are counteracted behaviorally. The third experiment measured autonomic heat loss and heat production. Decreases in Tb were caused by increased heat loss during the first 15-30 minutes post-PHEN. In addition, heat production increased after the drop in Tb. These results suggest that PHEN lowers Tb by altering thermoregulatory effectors, not by lowering thermal set-point.
Issue Date:1990
Rights Information:Copyright 1990 Kent, Stephen Patric Terrance
Date Available in IDEALS:2011-05-07
Identifier in Online Catalog:AAI9114289
OCLC Identifier:(UMI)AAI9114289

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