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Phosphorus-31 nuclear magnetic resonance spectroscopy of human uterus and placenta

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Title: Phosphorus-31 nuclear magnetic resonance spectroscopy of human uterus and placenta
Author(s): Raman, Jyothi
Doctoral Committee Chair(s): Dawson, M. Joan
Department / Program: Biophysics and Computational Biology
Discipline: Biophysics
Degree Granting Institution: University of Illinois at Urbana-Champaign
Degree: Ph.D.
Genre: Dissertation
Subject(s): Health Sciences, Obstetrics and Gynecology Health Sciences, Radiology Biophysics, Medical
Abstract: This thesis aims to demonstrate the usefulness of Nuclear Magnetic Resonance Spectroscopy in understanding normal human placental and uterine metabolism as well as its application in the study of gestational and gynecological disorders. We have used phosphorus-31 NMR spectroscopy on isolated samples of placenta and uterus (myometrium and endometrium). Our studies have revealed interesting correlations between spectral characteristics and the type of tissue studied, normal and abnormal.The $\sp{31}$P spectrum of placenta changes as it matures with increasing gestational age. In addition, complications of pregnancy, including intrauterine growth-retardation and hydatidiform mole, are associated with significant changes in the placental spectrum. Absolute volume of intracellular water and intracellular concentrations of normal placental phosphorus metabolites were obtained.The effects of pregnancy are manifested in the NMR spectra of normal pregnant myometria. Experiments on nonpregnant diseased uterus have revealed presence of disease in histologically normal tissue obtained close to a uterine lesion. We have also demonstrated feasibility and cost-effectiveness of evaluation of endometrial biopsies by NMR prior to histopathological examination.
Issue Date: 1991
Type: Text
Language: English
Rights Information: Copyright 1991 Raman, Jyothi
Date Available in IDEALS: 2011-05-07
Identifier in Online Catalog: AAI9136708
OCLC Identifier: (UMI)AAI9136708

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