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Type I repressors of P element mobility

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Title: Type I repressors of P element mobility
Author(s): Gloor, Gregory B.; Preston, Christine R.; Johnson-Schlitz, Dena M.; Nassif, Nadine A.; Phillis, Randall W.; Benz, Wendy K.; Robertson, Hugh M.; Engels, William R.
Subject(s): Genetics
Abstract: We describe here a family of P elements that we refer to as type I repressors. These elements are identified by their repressor functions and theilra ck of any deletion within the first two-thirds of the canonical P sequence. Elements belonging to this repressor class were isolated from P strains and were made in vitro. We found that type I repressor elements could strongly repress botha cytotypedependent allele and P element mobility in somatic and germline tissues. These effects were very dependent on genomic position. Moreover, we observed that an element’s ability to repress in one assay positively correlated with its ability to repress in either of the other two assays. The type I family of repressor elements includes both autonomous P elements and those lacking exon 3 of the P element. Fine structure deletion mapping showed that the minimal 3‘ boundary of a functional type I element lies between nucleotide position 1950 and 1956. None of 12 elements examined with more extreme deletions extending into exon 2 made repressor. We conclude that the type I repressors form a structurally distinct group that does not include more extensively deleted repressor elements such as the KP element described previously.
Issue Date: 1993-09
Publisher: Genetics Society of America
Citation Info: Gloor, G. B., C. R. Preston, D. M. Johnson-Schlitz, N. A. Nassif, R. W. Phillis, W. K. Benz, H. M. Robertson and W. R. Engels 1993. Type I repressors of P element mobility. Genetics 135, 81-95.
Genre: Article
Type: Text
Language: English
URI: http://hdl.handle.net/2142/220
Publication Status: published or submitted for publication
Peer Reviewed: is peer reviewed
Rights Information: Copyright owned by Genetics Society of America
Date Available in IDEALS: 2007-02-13
 

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