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Title:Investigations of chiral recognition of conformationally rigid chiral stationary phases
Author(s):Lee, Wonjae
Doctoral Committee Chair(s):Pirkle, William H.
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:From mechanistic considerations, the development of conformationally rigid chiral stationary phases (CSPs) has been a goal. Several conformationally rigid CSPs derived from $\alpha$-amino-lactams have been prepared and their abilities to separate the enantiomers of a variety of analytes have been evaluated. $\pi$-Acidic $\alpha$-amino-$\beta$-lactam-derived CSPs have been designed specifically for the enantioseparation of underivatized $\beta$-blockers. A systematic study of chromatographic structure-activity relationships for the resolution of $\pi$-acidic dinitrobenzoyl (DNB) amino acid derivatives on several DNB $\pi$-acidic CSPs has been carried out. Related to these studies, X-ray crystallographic structure determinations have been pursued in a quest for the origins of chiral-self recognition.
Issue Date:1994
Type:Text
Language:English
URI:http://hdl.handle.net/2142/22235
Rights Information:Copyright 1994 Lee, Wonjae
Date Available in IDEALS:2011-05-07
Identifier in Online Catalog:AAI9512455
OCLC Identifier:(UMI)AAI9512455


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