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 Title: Analyses and predictions of ultrasound interactions with model biomembrane systems via two-state transition model Author(s): Tata, Darayash Burjor Doctoral Committee Chair(s): Dunn, Floyd Department / Program: Biophysics and Computational Biology Discipline: Biophysics and Computational Biology Degree Granting Institution: University of Illinois at Urbana-Champaign Degree: Ph.D. Genre: Dissertation Subject(s): Chemistry, Physical Engineering, Biomedical Physics, Acoustics Abstract: Low intensity ultrasound (approximately 10$\sp{-6}$ W/cm$\sp2$) in the frequency range of 0.5 MHz to 5.0 MHz was employed to investigate biomembrane structural relaxation kinetics via absorption and velocity dispersion spectroscopy. The multilamellar vesicles utilized in this investigation were either composed of pure phospholipids or mixtures of phospholipids and small molar fractions of protein gramicidin. The experimental findings reveal enhanced ultrasound interactions near to the lipid phase transition temperature. The enhanced ultrasound absorption spectra closely resemble single relaxation spectra, suggesting that the membrane constituents undergo a simple two-state transition. The temperature dependence of the relaxation frequency is followed with the combined aid of the absorption and velocity dispersion spectrum. Thermodynamic and electrical capacitor two-state transition models are developed to help describe the observed phenomena and to predict to a reasonable degree of accuracy the enhanced findings promoted by ultrasound. Issue Date: 1991 Type: Text Language: English URI: http://hdl.handle.net/2142/23330 Rights Information: Copyright 1991 Tata, Darayash Burjor Date Available in IDEALS: 2011-05-07 Identifier in Online Catalog: AAI9211009 OCLC Identifier: (UMI)AAI9211009
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