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Title:Individual differences in cocaine's locomotor activating effects predicts reward-directed behavior
Author(s):Venheim, Emily R.
Advisor(s):Gulley, Joshua M.
Department / Program:Psychology
Degree Granting Institution:University of Illinois at Urbana-Champaign
individual differences
Abstract:Humans exhibit marked individual differences in susceptibility to develop drug dependence. Addiction-like behaviors have been modeled in rodents as well with similar individual variability in the development of addiction-like behaviors. One potential mechanism that could differentiate addiction-vulnerable from addiction-resistant individuals is sensitivity to reward-paired cues. Pavlovian-instrumental transfer (PIT) is a paradigm that assesses the extent to which reward cues can initiate previously unpaired instrumental responding for a common reward. To examine the potential that sensitivity to reward-paired cues is a mechanism differentiating individuals with a propensity to develop addiction-like behaviors, we used a rodent model known to differ in initial responsiveness to cocaine as well as in behaviors implicated in ‘addiction-vulnerability’. We hypothesize that rodents displaying the ‘addiction-vulnerable’ phenotype will initiate instrumental responding to a greater degree when presented with cues associated with reward than their counterparts.
Issue Date:2011-05-25
Rights Information:
Copyright 2011 Emily R. Venheim
Date Available in IDEALS:2011-05-25
Date Deposited:2011-05

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