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Title:Amino acid N-carboxyanhydrides and polypeptides: Controlled polymerization, properties and applications
Author(s):Lu, Hua
Director of Research:Cheng, Jianjun
Doctoral Committee Chair(s):Cheng, Jianjun
Doctoral Committee Member(s):Braun, Paul V.; Economy, James; Moore, Jeffrey S.
Department / Program:Materials Science & Engineerng
Discipline:Materials Science & Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):N-carboxyanhydrides (nca)
Helix gene-delivery
Abstract:The goal of my Ph.D. research is to develop controlled/living polymerization techniques of α-amino acid N-carboxyanhydrides (NCAs) and synthetic polypeptides based materials. Polypeptides are a class of emerging biomaterials receiving increasing interests for various applications including drug delivery, gene therapy, antimicrobial and tissue engineering. The ring-opening polymerization (ROP) of NCAs has long been demonstrated as a powerful technique for preparation of high molecular weight (MW) synthetic polypeptides in gram scale. We developed a system utilizing organo-silicon amines, namely hexamethyldisilazane (HMDS) and N-trimethylsilyl (N-TMS) amines, for the controlled ROP of various NCAs. Predicable MWs and narrow molecular weight distributions (MWDs) of homo- and block- polypeptides can be prepared via this methodology. Our mechanism study illustrated that the polymerization involves formation of trimethylsilyl carbamate (TMS-CBM) structure at the propagation center. In addition, the system allows facile end group and side-chain functionalization of the polypeptides and integration of NCA ROP with other polymerization techniques such as ring-opening metathesis polymerization (ROMP) to prepare hybrid polypeptides materials. Finally, we discovered a new type of ionic polypeptides with unusual helical stability and demonstrated that they have great potential for gene delivery and siRNA delivery applications.
Issue Date:2011-05-25
Rights Information:Copyright 2011 Hua Lu
Date Available in IDEALS:2011-05-25
Date Deposited:2011-05

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