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Title: Amino acid N-carboxyanhydrides and polypeptides: Controlled polymerization, properties and applications
Author(s): Lu, Hua
Director of Research: Cheng, Jianjun
Doctoral Committee Chair(s): Cheng, Jianjun
Doctoral Committee Member(s): Braun, Paul V.; Economy, James; Moore, Jeffrey S.
Department / Program: Materials Science & Engineerng
Discipline: Materials Science & Engr
Degree Granting Institution: University of Illinois at Urbana-Champaign
Degree: Ph.D.
Genre: Dissertation
Subject(s): N-carboxyanhydrides (nca)
Polypeptides
Controlled-polymerization
Helix gene-delivery
Abstract: The goal of my Ph.D. research is to develop controlled/living polymerization techniques of α-amino acid N-carboxyanhydrides (NCAs) and synthetic polypeptides based materials. Polypeptides are a class of emerging biomaterials receiving increasing interests for various applications including drug delivery, gene therapy, antimicrobial and tissue engineering. The ring-opening polymerization (ROP) of NCAs has long been demonstrated as a powerful technique for preparation of high molecular weight (MW) synthetic polypeptides in gram scale. We developed a system utilizing organo-silicon amines, namely hexamethyldisilazane (HMDS) and N-trimethylsilyl (N-TMS) amines, for the controlled ROP of various NCAs. Predicable MWs and narrow molecular weight distributions (MWDs) of homo- and block- polypeptides can be prepared via this methodology. Our mechanism study illustrated that the polymerization involves formation of trimethylsilyl carbamate (TMS-CBM) structure at the propagation center. In addition, the system allows facile end group and side-chain functionalization of the polypeptides and integration of NCA ROP with other polymerization techniques such as ring-opening metathesis polymerization (ROMP) to prepare hybrid polypeptides materials. Finally, we discovered a new type of ionic polypeptides with unusual helical stability and demonstrated that they have great potential for gene delivery and siRNA delivery applications.
Issue Date: 2011-05-25
URI: http://hdl.handle.net/2142/24190
Rights Information: Copyright 2011 Hua Lu
Date Available in IDEALS: 2011-05-25
Date Deposited: 2011-05


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