The use of a combination of surveillance methods is the most effective way of assessing Lyme disease risk in an area where risk is unknown. Significant environmental determinants can be identified using a GIS, and a risk ...

Pseudorabies virus (PRV) is an alphaherpesvirus of swine that causes significant morbidity in adult populations, morbidity and mortality in young pigs, and economic losses to the swine industry each year. Evidence suggests ...

For decades, the study of aryl hydrocarbon receptor (AhR), a transcription factor and a member of the basic helix-loop-helix/Per-ARNT-Sim (bHLH-PAS) domain family, has been focused on its role in mediating adverse effects ...

In recent years, the neuropeptide kisspeptin, secreted by kisspeptin neurons, has been identified as the prime regulator of gonadotropin releasing hormone (GnRH). Kisspeptin neurons express steroid hormone receptors through ...

Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, causes a costly global disease of swine. PRRSV infects their alveolar macrophages (AMΦ) resulting in an interstitial pneumonia. The ability of ...

Between 2004 and 2016, the number of human tick-borne disease (TBD) cases doubled and seven new tick-borne pathogens that can infect humans were discovered within the United States. Because tick exposure and the risk of ...

Perturbations in the developing nervous system have been associated with perinatal exposures to polychlorinated biphenyls (PCBs). To determine which PCBs accumulate in brain following perinatal exposure, Sprague-Dawley ...

Microcystin-LR (MCLR), produced by the blue-green alga Microcystis aeruginosa, causes death of livestock and is a public health hazard. The mechanism of MCLR toxicity was investigated using the rat. Changes in serum chemistry ...

A newly discovered Trypanosoma cruzi phosphoinositide phospholipase C (TcPI-PLC) is lipid modified in its N-terminus, and located in the plasma membrane of amastigotes. The N-terminal 20 amino acids of TcPI-PLC contain ...