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Title:Instrumentation for a distributed feedback laser biosensor system
Author(s):Chu, Allen C.
Advisor(s):Cunningham, Brian T.
Department / Program:Electrical & Computer Eng
Discipline:Electrical & Computer Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Distributed Feedback Laser
Biochemical Assay
Label Free
Biomolecular Detection
Small Molecule Interaction
Abstract:The development of the instrumentation behind a biosensor system based on a vertically emitting distributed feedback laser is presented. The performance of the label-free high-resolution biomolecular detection system is optimized for use in applications that require the study of large quantities of parallel interactions that could be adversely affected by the use of molecular labels, such as high-throughput pharmaceutical drug screenings. A series of filtering and averaging methods for minimizing the effects of sensor noise are discussed in the analysis of both single spectrum measurements and kinetic scans over time. An example biochemical assay is performed to demonstrate and evaluate the current capabilities of the biosensor system. Plans for the future advancement of the system, including the possibilities of hardware improvements, device fabrication refinements, data analysis enhancements, and new usage models, are considered.
Issue Date:2011-08-25
Rights Information:Copyright 2011 Allen C. Chu
Date Available in IDEALS:2011-08-25
Date Deposited:2011-08

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