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Title:Glassy models of protein folding
Author(s):Bryngelson, Joseph Donald
Doctoral Committee Chair(s):Wolynes, P.G.
Department / Program:Physics
Discipline:Physics
Degree:Ph.D.
Genre:Dissertation
Subject(s):glassy models
protein folding
Abstract:In this thesis we have used concepts from the physics of disordered materials to study protein folding. The first chapter consists of a general introduction to proteins and protein folding. In Chapter Two we develop a simple protein folding model and use a random energy approximation to calculate its equilibrium properties. The model has unfolded, folded and glassy phases. In Chapter Three we investigate the dynamics of the model. The model has many metastable states and the distribution of the lifetimes of these states is log-normal at high temperatures and becomes much broader in the glassy phase. Also, we calculate the folding time by deriving a generalization of transition state theory that takes into account some of the glassy behavior of our model. The results for the folding time are physically reasonable. In Chapter Four we combine the ideas of the preceding chapters with the theory of polymer collapse. First we study the collapse of random hetropolymers and find that hetropolymers have a frozen collapsed phase that does not occur in homopolymers. Then we study the equilibrium properties and folding time of a model of protein folding that incorporates some features of polymer collapse. The properties of this model are found to be qualitatively similar to those of our earlier model. We also find that in this new model the rate limiting step in folding occurs after much of the native structure has been formed, which agrees with experiments.
Issue Date:1988
Genre:Dissertation / Thesis
Type:Text
Language:English
URI:http://hdl.handle.net/2142/30681
Other Identifier(s):1565952
Rights Information:©1988 Bryngelson
Date Available in IDEALS:2012-04-19


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