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Title:Physical models of protein folding within the energy landscape theory
Author(s):Plotkin, Steven S.
Doctoral Committee Chair(s):Wolynes, P.G.
Department / Program:Physics
Discipline:Physics
Degree:Ph.D.
Genre:Dissertation
Subject(s):protein folding
energy landscape theory
potential energy surface
partially random heteropolymer
Abstract:The energy landscape theory of protein fol9.ing is based on a statistical description of a protein's complex potential energy surface. Individual folding events are sampled from an ensemble of possible routes on the landscape. The theory suggests that the landscape of a protein can be described as that of a partially random heteropolymer with a rugged, yet funnelled landscape towards the native structure. The quantitative aspects of folding are developed using tools from the statistical mechanics of disordered systems, polymers, and phase transitions of finite systems. The theory provides an interpretation of results from fast folding experiments as well as minimalist models used in computer simulations.
Issue Date:1998
Genre:Dissertation / Thesis
Type:Text
Language:English
URI:http://hdl.handle.net/2142/30847
Other Identifier(s):4161509
Rights Information:©1998 Plotkin
Date Available in IDEALS:2012-05-15


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