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Title:Non-invasive assessment of bacterial biofilm in the middle ear using low-coherence interferometry/optical coherence tomography and acoustic measurements
Author(s):Nguyen, Cac
Director of Research:Boppart, Stephen A.
Doctoral Committee Chair(s):Boppart, Stephen A.
Doctoral Committee Member(s):Blahut, Richard E.; Allen, Jont B.; Novak, Michael A.
Department / Program:Electrical & Computer Eng
Discipline:Electrical & Computer Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Middle ear infection
Bacterial biofilm
Low coherence interferometry
Optical coherence tomography
Abstract:Otitis media (OM) is a middle ear infection caused by bacterial growth between the tympanic membrane (TM) and the inner ear. Children with chronic OM, including OM with effusion and recurrent OM, often have conductive hearing loss and communication difficulties, and need surgical treatment. Recent clinical studies have shown strong evidence that there is a one-to-one correspondence between chronic OM and the presence of a bacterial biofilm behind the TM. This thesis proposes an approach to investigate bacterial biofilm in the middle ear using two methods, low coherence interferometry (LCI)/optical coherent tomography (OCT) and acoustic measurements. Portable systems were constructed by integrating LCI/OCT techniques with a standard video otoscope to provide depth-resolved optical scattering properties of the middle ear. An automatic algorithm was written to classify the LCI/OCT data to detect the presence of biofilm behind the TM and therefore distinguish the chronic infection. The acoustic measurement provides multi-frequency reflectance and impedance characteristics of the middle ear. These acoustic measurements are then represented by pole-zero plots, which are then analyzed to determine physical acoustic characteristics and to synthesize models of the middle ear.
Issue Date:2012-09-18
URI:http://hdl.handle.net/2142/34215
Rights Information:Copyright 2012 Cac Nguyen
Date Available in IDEALS:2012-09-18
Date Deposited:2012-08


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