Files in this item



application/pdfEleni_Antoniadou.pdf (2MB)
(no description provided)PDF


Title:The interplay of matrix rigidity and mechanical stretching for the development of artificial skin
Author(s):Antoniadou, Eleni
Advisor(s):Kong, Hyun Joon
Department / Program:Bioengineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Matrix stiffness
Mechanical stretching
artificial skin
tissue engineering
Abstract:Tissue engineering and regenerative medicine provides the possibility for generating organs in laboratorial settings as an off-the-shelf-technology that can provide an alternative therapeutic pathway for transplantations and replace non-functional organs. Many engineered tissues have been attempted in the past decade including skin, blood vessel, cartilage and bone but they lack the mechanical properties and biological functionality of their real counterparts which leads to failure in vivo. Matrix rigidity and mechanical forces are key regulators of tissue homeostasis and are essential for tissue formation, remodeling and healthy function. As a consequence, mechanical stimulation has frequently been employed to improve tissue morphogenesis, and cellular spatial organization but it has not been previously implemented in a synergistic manner with matrix rigidity due to lack of tools in 3D cell culture systems. The goal of this study is to investigate the structural changes, the morphological alterations and tissue formation by developing a novel 3D construct that is resilient with controlled matrix stiffness and which can sustain mechanical strain. This template can be used to further elucidate the biochemical pathways for stem cell differentiation that result into the regeneration of a series of tissues.
Issue Date:2013-02-03
Rights Information:Copyright 2012 Eleni Antoniadou
Date Available in IDEALS:2013-02-03
Date Deposited:2012-12

This item appears in the following Collection(s)

Item Statistics