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Title:Environmental and genetic variation of the anti-cancer peptides lunasin and Bowman-Birk protease inhibitor in Glycine max
Author(s):Walton, Daniel
Advisor(s):Nelson, Randall L.
Department / Program:Crop Sciences
Discipline:Crop Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Bowman-Birk protease inhibitor (BBI)
bioactive compounds
genetic variation
environmental variation
time course
Abstract:The economic importance of soybean (Glycine max) as a foodstuff has, in recent years, been supplemented by its importance as a source of bioactive compounds. Two of these compounds, the Bowman-Birk protease inhibitor (BBI) and the peptide lunasin, exhibit anti-cancer properties, and clinical studies suggest that the two may act in a complementary fashion. The present work surveys the levels of these two compounds across a time course of soybean development, a number of diverse soybean genotypes from the USDA Soybean Germplasm Collection, and a collection of soybean lines grown at Urbana and Bellflower, IL in the summer of 2012. Concentrations of BBI measured across mature lines in the study ranged from .101 to .38 mg/g defatted seed, while concentrations of lunasin ranged from 1.06 to 6.12 mg/g defatted seed. BBI and lunasin were significantly correlated through seed development (p = .0097), but concentrations of the compounds were not related in mature seeds. Genotype and the interaction of genotype by environment were found to significantly impact BBI (p = .03; p = .01), and this interaction effect was found to vary in direction depending on genotype. Environment (p = .03) and genotype had significant effects (p = .03; p < .01) on lunasin. Soil moisture may be the most important environmental factor in determining lunasin concentrations.
Issue Date:2013-05-24
Rights Information:Copyright 2013 Daniel Walton
Date Available in IDEALS:2013-05-24
Date Deposited:2013-05

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