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Title:Synthesis and characterization of nanoparticle suspensions: towards quantitative surface-enhanced Raman spectroscopic sensing
Author(s):Devetter, Brent
Advisor(s):Bhargava, Rohit
Department / Program:Electrical & Computer Eng
Discipline:Electrical & Computer Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):surface-enhanced Raman spectroscopy
gold nanoparticles
chemical sensing
Abstract:Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive technique with applications ranging from in vitro and in vivo biological sensing to chemical and explosives detection. In this thesis, we explore the design and characterization of suspensions of nanoparticles prior to their use for SERS-based molecular sensing. A major problem in SERS-based measurements is that the signals are often not interpreted quantitatively. Measurements performed in suspension mimic the nanoprobe-to-nanoprobe optical interactions expected to be found in tissues with embedded nanoprobes while particle-level measurements of synthesized nanoparticles provide the molecular basis for calculations. We find that careful consideration of the localized surface plasmon resonance of SERS nanoprobes with respect to laser excitation wavelength is essential for maximizing detectable SERS signal. Additionally, the reporter molecule load per particle depends on synthesis conditions and the shape of the nanoparticles. Together, well-characterized suspensions can be used to understand the molecular and electromagnetic aspects of recorded SERS data.
Issue Date:2013-05-24
Rights Information:Copyright 2013 Brent Devetter
Date Available in IDEALS:2013-05-24
Date Deposited:2013-05

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