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Title:Mid infrared spectroscopic imaging and tomography
Author(s):Reddy, Rohith
Director of Research:Bhargava, Rohit
Doctoral Committee Chair(s):Bhargava, Rohit
Doctoral Committee Member(s):Carney, Paul S.; Do, Minh N.; Ahuja, Narendra
Department / Program:Bioengineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Fourier Transform Infrared (FT-IR) spectroscopic Imaging
Mid-Infrared Spectroscopic Tomography
Spectroscopic Imaging
Spectroscopic Tomography
mid-Infrared (Mid-IR)
Abstract:Fourier Transform Infrared (FT-IR) Spectroscopic Imaging is an optical technique that simultaneously provides morphological (two dimensional) and mid-infrared spectral (one dimensional) information for a specimen under observation. In this dissertation, we develop a new instrument that extends the capabilities of FT-IR imaging to provide three dimensional morphological information along with mid-infrared spectral information on the microscopic length scale. We first demonstrate that spectroscopic information from the mid-infrared can be used to perform histologic recognition and cancer detection in prostate, breast and skin cancer tissues. These studies utilize FT-IR imaging data of thin tissue slices from several hundred patients. The segmentation algorithms and instrumentation used are described in detail. We perform a rigorous analysis of instrumentation and data so as to understand the limits and limitations of current state-of-the-art instrumentation. We then propose a new instrument that adds a new dimension of information to current instruments and establish the new state-of-the-art in mid-infrared imaging. The theoretical basis of such instrumentation is presented in detail and techniques for visualization of four dimensional data are outlined.
Issue Date:2013-05-28
Rights Information:Copyright 2013 Rohith Reddy
Date Available in IDEALS:2013-05-28
Date Deposited:2013-05

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