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Title:Transcriptional regulation of metabolism and behavior: insights from reconstruction and modeling of complex biochemical networks
Author(s):Chandrasekaran, Sriram
Director of Research:Price, Nathan D.
Doctoral Committee Chair(s):Price, Nathan D.
Doctoral Committee Member(s):Robinson, Gene E.; Luthey-Schulten, Zaida A.; Zhong, Sheng
Department / Program:School of Molecular & Cell Bio
Discipline:Biophysics & Computnl Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Systems Biology
Metabolism
Gene Regulation
Social Behavior
Neuroscience
Machine learning
Genomics
Data Mining
Abstract:The genotype and the environment significantly influence the behavior and phenotype of an organism. Yet the mechanism by which a simple genetic change or environmental perturbation alters the state of an organism at the molecular level, and subsequently its phenotype, is still not completely clear. Large-scale omics experiments are now generating a wealth of data on these various processes. As a result, there is a critical need for methods that rapidly transform these high-throughput data into predictive models for medicine and bioengineering. These predictive models need to seamlessly integrate molecular components of the cell into networks and subsequently predict macroscopic phenotypic changes that emerge from these interacting networks. I have developed new tools and algorithms that address this key challenge of multi-scale network integration in order to assemble a holistic view of the cell. My dissertation involves three main themes: 1. The development of new tools (PROM, GEMINI and ASTRIX) for reconstruction and modeling of biochemical networks 2. Understanding transcriptional regulation of metabolism in various model organisms 3. Applying systems approaches to social behavior to dissect the role of transcriptional regulation.
Issue Date:2013-08-22
URI:http://hdl.handle.net/2142/45486
Rights Information:Copyright 2013 Sriram Chandrasekaran
Date Available in IDEALS:2013-08-22
Date Deposited:2013-08


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