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Title:High-speed polarization-sensitive optical coherence tomography: toward intraoperative cancer imaging
Author(s):South, Fredrick
Advisor(s):Boppart, Stephen A.
Department / Program:Electrical & Computer Eng
Discipline:Electrical & Computer Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):biomedical imaging
optical coherence tomography
breast cancer
Abstract:Successful treatment of most breast cancers requires surgical removal of the tumor. The current standard-of-care does not provide any tools for real-time assessment of the tumor cavity. Optical coherence tomography (OCT) has previously been developed for real-time intraoperative use in hopes of aiding tumor margin assessment. While there has been much success, it remains difficult to distinguish between normal stroma tissue and breast cancer. Polarization-sensitive optical coherence tomography (PS-OCT) is an extension of OCT that measures both the intensity and polarization of light returning from the tissue. PS-OCT is sensitive to changes in collagen structure and may provide additional contrast between normal and diseased tissue. This thesis reports the development of a real-time PS-OCT system using a high-speed swept-source laser and parallel processing on a graphics processing unit (GPU). Results of a preliminary imaging study are also reported, demonstrating that PS-OCT provides enhanced contrast between previously indistinguishable fibrous stroma and invasive ductal carcinoma (IDC).
Issue Date:2014-01-16
Rights Information:Copyright 2013 Fredrick South
Date Available in IDEALS:2014-01-16
Date Deposited:2013-12

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