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Title:Towards simultaneous single emission microscopy and magnetic resonance imaging
Author(s):Cai, Liang
Director of Research:Meng, Ling Jian
Doctoral Committee Chair(s):Meng, Ling Jian
Doctoral Committee Member(s):Stubbins, James F.; Sullivan, Clair Julia; Sutton, Bradley P.
Department / Program:Nuclear, Plasma, & Rad Engr
Discipline:Nuclear, Plasma, Radiolgc Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Magnetic Resonance Single Photon Emission Computed Tomography (MR-SPECT)
semiconductor detector
Cadmium Telluride (CdTe)
System development
Abstract:In recent years, the combined nuclear imaging and magnetic resonance imaging (MRI) has drawn extensive research effort. They can provide simultaneously acquired anatomical and functional information inside the human/small animal body in vivo. In this dissertation, the development of an ultrahigh resolution MR-compatible SPECT (Single Photon Emission Computed Tomography) system that can be operated inside a pre-existing clinical MR scanner for simultaneous dual-modality imaging of small animals will be discussed. This system is constructed with 40 small pixel CdTe detector modules assembled in a fully stationary ring SPECT geometry. Series of experiments have demonstrated that this system is capable of providing an imaging resolution of <500μm, when operated inside MR scanners. The ultrahigh resolution MR-compatible SPECT system is built around a small pixel CdTe detector module that we recently developed. Each module consists of CdTe detectors having an overall size of 2.2 cm × 1.1 cm, divided into 64 × 32 pixels of 350 μm in size. A novel hybrid pixel-waveform (HPWF) readout system is also designed to alleviate several challenges for using small-pixel CdTe detectors in ultrahigh-resolution SPECT imaging applications. The HPWF system utilizes a modified version of a 2048-channel 2-D CMOS ASIC to readout the anode pixel, and a digitizing circuitry to sample the signal waveform induced on the cathode. The cathode waveform acquired with the HPWF circuitry offers excellent spatial resolution, energy resolution and depth of interaction (DOI) information, even with the presence of excessive charge-sharing/charge-loss between the small anode pixels. The HPWF CdTe detector is designed and constructed with a minimum amount of ferromagnetic materials, to ensure the MR-compatibility. To achieve sub-500μm imaging resolution, two special designed SPECT apertures have been constructed with different pinhole sizes of 300μm and 500μm respectively. It has 40 pinhole inserts that are made of cast platinum (90%)-iridium (10%) alloy, which provides the maximum stopping power and are compatible with MR scanners. The SPECT system is installed on a non-metal gantry constructed with 3-D printing using nylon powder material. This compact system can work as a “low-cost” desktop ultrahigh resolution SPECT system. It can also be directly operated inside an MR scanner. Accurate system geometrical calibration and corresponding image reconstruction methods for the MRC-SPECT system is developed. In order to account for the magnetic field induced distortion in the SPECT image, a comprehensive charge collection model inside strong magnetic field is adopted to produce high resolution SPECT image inside MR scanner.
Issue Date:2014-01-16
URI:http://hdl.handle.net/2142/46817
Rights Information:Copyright 2013 Liang Cai
Date Available in IDEALS:2014-01-16
2016-01-16
Date Deposited:2013-12


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