Files in this item

FilesDescriptionFormat

application/pdf

application/pdfJe_Choi.pdf (2MB)
(no description provided)PDF

Description

Title:Worm-shaped polymersomes and their effects on targeting efficiency
Author(s):Choi, Je
Advisor(s):Kong, Hyun Joon
Department / Program:Chemical & Biomolecular Engr
Discipline:Chemical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:M.S.
Genre:Thesis
Subject(s):particle shape
Abstract:In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability than spherical polymersomes. Morphology of the resulting polymersome was observed afterwards. The polymersome was further modified to present Arg-Gly-Asp (RGD) motif, which is known to bind with cells that overexpress integrins. The binding affinities of the polymersomes onto target substrates were assessed using surface plasmon resonance (SPR) spectroscopy and adherence of the polymersomes to a target cell layer was also evaluated using flow chamber simulating blood flow.
Issue Date:2014-01-16
URI:http://hdl.handle.net/2142/46914
Rights Information:Copyright 2013 Je Choi
Date Available in IDEALS:2014-01-16
2016-01-16
Date Deposited:2013-12


This item appears in the following Collection(s)

Item Statistics