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Browse Graduate Dissertations and Theses at Illinois by Contributor "Ha, Taekjip"
Now showing items 1-20 of 61
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(2006-10)
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(2015-07-15)Analysis of somatic alterations in cancer genomes has been accelerated through the rapid growth of the quantity, quality and depth of data generated by next-generation sequencing (NGS). Previously most of cancer genome ...
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(2011-05-25)The folding of interphase chromatin into large-scale chromatin structure and its spatial organization within nucleus has been suggested to have important roles in gene regulation. In this study, we created engineered ...
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Binding configurations of single-stranded DNA binding protein and their influence on DNA recombinase (2015-04-22)DNA inside a cell is continuously damaged through multiple mechanisms including environmental exposure to radiation, chemical agents, or UV light. Certain products of the cell's own metabolism, such as reactive oxygen ...
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(2012-02-06)Laser cooling and trapping of the most magnetic fermionic atom, dysprosium (Dy), may provide a framework to explore quantum liquid crystal (QLC) theory (Chapter 1). This thesis presents details of the Dy laser cooling and ...
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(2016-04-29)The well-established dependence of cell traction forces on the compliance of supporting matrices has been attributed to levels of force exerted on components in focal contacts. Here, use of novel, force-limited nanoscale ...
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(2015-11-24)Fluorescence microscopy has been an essential tool in biology. However, its imaging resolution has been limited around >200 nm in lateral dimensions, and >500 nm in axial dimension, leaving many biological structures too ...
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(2010-08-20)In this article, three biological inquiries on cellular functions investigated through a combination of theoretical and computational methods are discussed: the morphology of the biological membrane, assembly of a multi-protein ...
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(2010-05-20)Evolutionary transitions, times at which the behavior of evolution as a dynamic system dramatically changes, have occurred many times throughout the history of life on Earth. Carl Woese proposed that one such transition ...
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(2016-11-16)Nucleic acids, including DNA and RNA, are one of the most important biomacromolecules inside the cell. DNA stores genetic information, while RNA has more versatile roles including conveying and deciphering genetic information, ...
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(2013-05-24)Although it is known that single-stranded DNA binding proteins (SSB) can stimulate helicase activity, the mechanism by which this occurs may be more complex than sequestering ssDNA products of duplex separation. Here, ...
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(2015-03-24)Conformational transitions in a protein and its interaction with the cognate substrate exemplify two important biomolecular processes that may be correlated, uncorrelated, or partially correlated. While the degree to which ...
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(2005-10-10)Carbon nanotubes are building blocks of the fast-developing nanotechnology that leads to revolutionary breakthroughs in material science and engineering. The extraordinary mechanical, electrical, and optical properties of ...
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(2014-01-16)The ribosome is a large macromolecular assembly responsible for protein synthesis in all living cells. A typical bacterial ribosome consists of three ribosomal RNA (rRNA) molecules and approximately fifty ribosomal proteins ...
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(2014-10-29)In the last 15 years, single molecule techniques have allowed us to observe the transient, heterogeneous, and multi‐step behavior of biomolecules often averaged out and lost in ensemble assays. Helicases form a ubiquitous ...
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(2014-10-29)In the last 15 years, single molecule techniques have allowed us to observe the transient, heterogeneous, and multi‐step behavior of biomolecules often averaged out and lost in ensemble assays. Helicases form a ubiquitous ...
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Exploring Novel Techniques for the Single Molecule Toolkit: Vesicle Encapsulation and Immobilization (2006)Tracking asynchronous time evolution of single biological molecules provides unique insights into detailed reaction kinetics and pathways. Such measurements are frequently made on macromolecules that are tethered on a glass ...
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(2013-02-03)Recent advances in single-molecule fluorescence imaging techniques have allowed the direct observation of protein dynamics on DNA, but the progress has been largely limited to double-stranded DNA (dsDNA) or short single-stranded ...
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(2012-02-01)Fluorescence resonance energy transfer (FRET) is used to monitor the metal ion dependent conformational change of the UO22+ specific DNAzyme 39E. Inactive metal ions, Mg2+ and Zn2+ are found capable of inducing folding ...
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(2012-06-27)During the past decade, various powerful single-molecule techniques have evolved and helped to address important questions in life sciences. As the single molecule techniques become mature, there is increasingly pressing ...
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Now showing items 1-20 of 61