Shp2 (Src Homology 2 Domain-containing Protein Tyrosine Phosphatase 2) is a pivotal player in various signaling pathways in response to growth factors. It contains two SH2 domains (N-SH2 and C-SH2), a phosphatase catalytic ...

Neutrophils play a critical role in host defense against invading pathogens. Chemotaxis, the directed migration of cells, allows neutrophil to seek out the sites of inflammation and infection. Neutrophil chemotaxis as well ...

Despite recent advances in our understanding of biochemical regulation of neutrophil chemotaxis, little is known about how mechanical factors control neutrophils’ persistent polarity and rapid motility. Here, by using a ...