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Title:Methods Development in Chiral Chromatography
Author(s):Mahler, George Stephen
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Chemistry, Organic
Abstract:Chiral stationary phases derived from N-3,5-dinitrobenzoyl amino acids, amides of 1-aryl-1-alkylamines and N-2-naphthyl amino acids have proven to be viable sorbents for the direct liquid chromatographic separation of enantiomers. In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies involving straightforward derivatization of commonly encountered compound types of practical interest have been developed. Protocols for the liquid chromatographic separation of the enantiomers of chiral heterocyclic amines, secondary alcohols, vicinal diols, and cyclopropyl amino acids are presented and their applications, limitations, and potentials are discussed. The suitability of these methodologies for analytical as well as preparative separations are discussed.
The use of N-3,5-dinitrobenzoyl-R-phenylglycine as a classical resolving agent for the resolution of several amines by formation of diastereomeric salts of differing solubilities is also considered.
Issue Date:1986
Type:Text
Description:174 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1986.
URI:http://hdl.handle.net/2142/70350
Other Identifier(s):(UMI)AAI8701556
Date Available in IDEALS:2014-12-15
Date Deposited:1986


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