Files in this item
|(no description provided)|
|Title:||Methods Development in Chiral Chromatography|
|Author(s):||Mahler, George Stephen|
|Department / Program:||Chemistry|
|Degree Granting Institution:||University of Illinois at Urbana-Champaign|
|Abstract:||Chiral stationary phases derived from N-3,5-dinitrobenzoyl amino acids, amides of 1-aryl-1-alkylamines and N-2-naphthyl amino acids have proven to be viable sorbents for the direct liquid chromatographic separation of enantiomers. In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies involving straightforward derivatization of commonly encountered compound types of practical interest have been developed. Protocols for the liquid chromatographic separation of the enantiomers of chiral heterocyclic amines, secondary alcohols, vicinal diols, and cyclopropyl amino acids are presented and their applications, limitations, and potentials are discussed. The suitability of these methodologies for analytical as well as preparative separations are discussed.
The use of N-3,5-dinitrobenzoyl-R-phenylglycine as a classical resolving agent for the resolution of several amines by formation of diastereomeric salts of differing solubilities is also considered.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1986.
|Date Available in IDEALS:||2014-12-15|