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|Title:||The Pathophysiology of Acute T-2 Mycotoxicosis in Swine (t-2 Toxin, Shock, Yellow Rain)|
|Author(s):||Lorenzana, Roseanne M.|
|Department / Program:||Veterinary Medical Science|
|Discipline:||Veterinary Medical Science|
|Degree Granting Institution:||University of Illinois at Urbana-Champaign|
|Subject(s):||Biology, Veterinary Science|
|Abstract:||The present study was conducted to characterize the nature of the shock syndrome that occurred in swine. It was hypothesized that the syndrome would be characterized by specific alterations in cardiovascular parameters, hematology, serum biochemistries, plasma concentrations of vasoactive substances, and plasma coagulation factors.
A single intravascular dose of 0.6 (n = 5) or 4.8 (n = 5) mg/kg T-2 toxin was given to swine. Another group of swine was given the vehicle (ethanol, n = 6) only. The animals were monitored until they died (high dose) or for 24 hours (low dose and control group). The high dose swine died between 5 1/2 and 10 1/2 hours.
Shock was characterized by reductions in cardiac output and blood pressure and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B(,2), 6-keto-PGF(,1(alpha)), and lactate. Total peripheral resistance was unchanged in the high dose group but decreased in the low dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and the partial pressure of arterial oxygen. There was a delayed increase in heart rate in both T-2 groups. No alteration occurred in plasma concentrations of histamine or serotonin.
Serum samples were collected at hourly intervals, and in the high dose group, increases occurred in creatinine, phosphorus, alkaline phosphatase, magnesium, and potassium. In both the high and low dose groups, increases occurred in urea nitrogen, aspartate aminotranferase, and a decrease occurred in total serum calcium. No significant trends occurred in the concentrations of ultrafilterable calcium, sodium, chloride, total protein, albumin, glucose, or total bilirubin.
An initial leukocytosis followed by a leukopenia in both groups. In the high dose group, the red blood cell count, hemoglobin concentration and hematocrit were increased. Nucleated red blood cells were seen in the blood smears of both groups.
Coagulation assays included prothrombin time, partial thromboplastin time, activated coagulation time, and fibrin degradation products. These clinical screening tests detected evidence of neither a coagulopathy nor disseminated intravascular coagulation.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1986.
|Date Available in IDEALS:||2014-12-16|
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Dissertations and Theses - Veterinary Clinical Medicine
Graduate Dissertations and Theses at Illinois
Graduate Theses and Dissertations at Illinois