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Title:A Brownian Dynamics Analysis of Ion Movement in Membrane Channels
Author(s):Cooper, Kimbal Edward
Department / Program:Physiology and Biophysics
Discipline:Physiology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biology, Animal Physiology
Abstract:The purpose of this thesis is to review and extend the theory of ion transport through membrane channel. A review of previous theory is presented which includes both Nernst-Planck and Eyring Rate theory approaches. The predictions and assumptions of the two theories are discussed and a unified derivation of both from a more fundamental stochastic theory is presented. That more fundamental stochastic theory is based on the Langevin equation. A simulation technique based on this equation is presented. The technique called Brownian dynamics is then used to study ion transport through membrane channels. Four cases are considered: (1) no ion-ion interaction, no channel structure; (2) no ion-ion interaction, channel structure present; (3) ion-ion interaction, no channel structure; (4) ion-ion interaction, channel structure present. A detailed discussion of the simulation is given with an indication of possible future improvements. The Brownian dynamic approach illustrates nicely the shortcomings of the Nernst-Planck and Eyring theory approaches.
Issue Date:1983
Type:Text
Description:220 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983.
URI:http://hdl.handle.net/2142/71425
Other Identifier(s):(UMI)AAI8409899
Date Available in IDEALS:2014-12-16
Date Deposited:1983


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