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|Title:||Longevity, Oxygen Toxicity and Radiation-Enhanced Resistance to Oxygen in Tribolium Confusum (Mortality, Hyperbaric, Radiation Factors, Induced Repair)|
|Author(s):||Lee, Yong Jun|
|Department / Program:||Physiology and Biophysics|
|Degree Granting Institution:||University of Illinois at Urbana-Champaign|
|Subject(s):||Health Sciences, Radiology|
|Abstract:||Sublethal doses of ionizing radiation increase longevity in a variety of insects, suggesting that irradiation may retard the age-dependent decline of physiological functions. There have been no systematic investigations of the response of irradiated populations to stress, however.
I have demonstrated that resistance of adult flour beetles, Tribolium confusum, to oxygen poisoning declines progressively with age. I have examined oxygen resistance of irradiated populations of T. confusum as a function of age at irradiation, of time after irradiation, and of radiation dose and of dose-modifying factors.
Shortly after gamma-irradiation, flour beetles exhibited a decline in resistance to oxygen toxicity. Then, about two weeks after irradiation, the LD(,50) exposure time in pure oxygen was much greater than that of nonirradiated beetles, and this enhanced resistance persisted for about 6 months. The magnitude of the enhancement was a function of dose, decreased with increasing age at irradiation, and was modified by radiation factors. Sublethal irradiation under anoxia, at low dose rate, or with dose fractionation reduced the development of oxygen resistance to approximately the same degree that it reduced acute radiation lethality. Spontaneous mortality rates and oxygen resistance are affected to about the same extent by radiation dose and by age at exposure. Radiation-enhanced resistance to stress may be an important factor in the increased longevity of irradiated insects.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1985.
|Date Available in IDEALS:||2014-12-16|
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Dissertations and Theses - Molecular and Integrative Physiology
Graduate Dissertations and Theses at Illinois
Graduate Theses and Dissertations at Illinois