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Title:Dynamics and Structures of Phospholipid Assemblies
Author(s):Yu, Yan
Doctoral Committee Chair(s):Granick, Steve
Department / Program:Materials Science and Engineering
Discipline:Materials Science and Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Chemistry, Physical
Biophysics, General
Engineering, Materials Science
Abstract:This thesis studies structures and dynamics of phospholipids vesicles and their interactions with nanoparticles and peptides, with a focus on the following problems: (1) Single-vesicle dynamics for new colloidal physics. Phospholipids vesicles are stabilized by physically adsorbed nanoparticles, and employed as a unique system, in which the vesicles in dense suspensions exhibits dynamical features corresponding to their soft, hollow and polydisperse characteristics. (2) Shape transformation of lipid membrane. Seeking a general understanding of shape deformations associated with biological functions and cell proliferation, morphologies of giant lipid vesicles are studied to reveal their interactions with nanoparticles and pore-forming peptides. Nanoparticle-induced pearling and peptide-induced raft budding of giant lipid vesicles provide facile strategies to reproduce cellular shape transformations in vitro . These studies bridge the cell biology with materials, chemistry and physics.
Issue Date:2009
Description:113 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
Other Identifier(s):(UMI)AAI3395557
Date Available in IDEALS:2014-12-17
Date Deposited:2009

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