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Title: | Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors |
Author(s): | Guerra, Francisco |
Director of Research: | Oldfield, Eric |
Doctoral Committee Chair(s): | Oldfield, Eric |
Doctoral Committee Member(s): | Nair, Satish K.; Gennis, Robert B.; Gruebele, Martin |
Department / Program: | School of Molecular & Cell Bio |
Discipline: | Biophysics & Computnl Biology |
Degree Granting Institution: | University of Illinois at Urbana-Champaign |
Degree: | Ph.D. |
Genre: | Dissertation |
Subject(s): | isoprenoid
iron-sulfur proteins 4Fe-4S bisphosphonate diphosphate |
Abstract: | The broad, long-term objective of this research is to develop drug leads for new antibiotics, antiparasitics, and cancer chemotherapeutics. Two main areas of focus are inhibition of the Methyl Erythritol Phosphate (MEP; non-mevalonate pathway) pathway in bacterial and parasitic human pathogens and inhibition of isoprenoid synthases in human cancers. For the development of antibacterials and antiparasitics, this research investigates the structure, function, and inhibition of the essential penultimate and ultimate enzymes of the MEP pathway, IspG (iron sulfur protein G; also known as GcpE and E-4-hydroxy-2-C-methyl-erythritol pyrophosphate synthase) and IspH (also know as LytB and E-4-hydroxy-2-C-methyl-erythritol pyrophosphate reductase), respectively. Investigation of novel cancer drugs focuses on mono- and combination therapies targeting the farnesyl pyrophosphate synthase (FPPS) and GGPPS (geranyl geranyl pyrophosphate synthase) enzymes with drugs that interact with several pathways involved in autophagy and apoptosis. |
Issue Date: | 2015-01-21 |
URI: | http://hdl.handle.net/2142/72983 |
Rights Information: | Copyright 2014 Francisco Guerra |
Date Available in IDEALS: | 2015-01-21 2017-01-22 |
Date Deposited: | 2014-12 |
This item appears in the following Collection(s)
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Dissertations and Theses - Molecular and Integrative Physiology
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Graduate Dissertations and Theses at Illinois
Graduate Theses and Dissertations at Illinois