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Title:General Features of Ligand Binding to Heme Proteins
Author(s):Yue, Kwok To
Department / Program:Center for Biophysics and Computational Biology
Discipline:Biophysics
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Biophysics, General
Abstract:The binding of ligands to heme proteins has been studied extensively in the past. A sequential barrier model was postulated. Using flash photolysis, various aspects of the model are studied in this work to give a better understanding of ligand binding. Binding from the pocket, as seen at low temperatures as process I, is examined under the influence of xenon binding, pH, high ligand concentration and Zn('++) ions. A new approach is developed to understand binding at physiological temperatures. The effect of solvent is examined with the new approach. The role of diffusion in binding is discussed. Support for a sequential model and the existence of conformational substates are presented. The effect of high ligand concentration on the kinetics is also investigated.
Issue Date:1983
Type:Text
Language:English
Description:112 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983.
URI:http://hdl.handle.net/2142/77477
Other Identifier(s):(UMI)AAI8310023
Date Available in IDEALS:2015-05-13
Date Deposited:1983


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