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Title:Mueller-matrix-based analysis for second-harmonic generation imaging
Author(s):Okoro, Chukwuemeka Onyekere
Department / Program:Electrical & Computer Eng
Discipline:Electrical & Computer Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Second-harmonic generation
Mueller matrix
Abstract:Second-harmonic generation microscopy takes advantage of second-order nonlinear property for imaging of biological structures. Invoking quantitative image analysis techniques facilitates the assessment of tissues in varying states. This thesis presents a quantitative description of the relative structural difference in collagen-based tissues by second harmonic generation (SHG) imaging techniques involving polarization investigation. The Mueller matrix formalism demonstrates a polarization-based analysis approach for assessment of varying samples. The associated second-order Mueller matrices are generated by applying image processing algorithms to sub-grids of image sets obtained from a forward imaging microscope. By defining scalar metrics such as the degree of polarization and the depolarization, a quantitative evaluation of the samples under investigation is provided. A discussion of the capabilities for tissue assessment and techniques for improvements in the data acquisition speed and analysis will also be proffered
Issue Date:2015-04-30
Rights Information:Copyright 2015 Chukwuemeka Okoro
Date Available in IDEALS:2015-07-22
Date Deposited:May 2015

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