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Title:Biomechanical regulation of epigenetics and chromatin organization in single living cells
Author(s):Tajik, Arash
Director of Research:Wang, Ning
Doctoral Committee Chair(s):Wang, Ning
Doctoral Committee Member(s):Wang, Yingxiao; Cheng, Jianjun; Nam, SungWoo; Ma, Jian
Department / Program:Mechanical Sci & Engineering
Discipline:Mechanical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Cell Mechanics
Chromatin Organization
Abstract:Mechanical forces are known to play a key role in regulating various cellular functions that control human development, cancer, disease, and aging. It, however, remains elusive how mechanical cues regulate biochemical mechanisms in the nucleus that control cellular decision-making. These mechanisms include epigenetic modification, chromatin organization, and gene expression. It is, therefore, highly important to investigate force-induced regulation of these mechanisms to better understand human physiology and disease. In this research, we aim at answering two key questions: one, how mechanical forces regulate epigenetics in tumor repopulating cells (TRCs), and two, how these forces unfold chromatin and induce gene expression in single living cells. Our findings suggest that mechanical forces play critical roles in regulating nuclear structure and function. Biomechanical cues can propagate deep inside the nucleus and regulate epigenetics, chromatin organization, and gene expression.
Issue Date:2015-04-13
Rights Information:Copyright 2015 Arash Tajik
Date Available in IDEALS:2015-07-22
Date Deposited:May 2015

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