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Title:Study of phenotypic and gene expression response to bacterial challenge
Author(s):Nixon, Scott Evan
Director of Research:Rodriguez-Zas, Sandra L.
Doctoral Committee Chair(s):Rodriguez-Zas, Sandra L.
Doctoral Committee Member(s):Caetano-Anollés, Gustavo; Chen, Xiaohui; Kelley, Keith W.
Department / Program:Graduate College Programs
Discipline:Informatics
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Behavior
Transcriptome
Functional Analysis
Abstract:In the mouse model of Bacillus Calmette-Guérin (BCG)-induced inflammation, focus is placed upon phenotypic and gene-expression responses to the original challenge. Studies of the phenotypic response to BCG involves several behavior indicators, categorized as representing an initial period of sickness response, and a set of depression-like behaviors that can endure for several weeks. Little is known about the impact of relationships among indicators on these studies, as most analyses have treated indicators independently. Gene-expression studies have also been small in scale, limiting what is known about gene-expression during these behavioral changes. With the availability of Next-Generation Sequencing platforms, the scale of transcriptome analysis can be greatly increased. This study aims to address these previous limitations, characterizing behavioral and gene-expression responses to BCG-induced inflammation.
Issue Date:2015-04-23
Type:Thesis
URI:http://hdl.handle.net/2142/78763
Rights Information:Copyright 2015 Scott Nixon
Date Available in IDEALS:2015-07-22
Date Deposited:May 2015


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