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Title:Image and Optical Property Reconstruction From Noninvasive Measurements of Turbid Media, in Vitro and in Vivo: A Promising Method for Optical Mammography
Author(s):Walker, Scott Andrew
Doctoral Committee Chair(s):Gratton, Enrico
Department / Program:Physics
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Engineering, Biomedical
Abstract:Before my work in this field, researchers were uncertain whether the diffusion model would be valid for a medium containing inhomogeneities. I, along with a handful of other researchers demonstrated that the diffusion model is accurate enough to include well behaved heterogeneous tissue models in which a number of macroscopic objects of different size and shape are embedded in a homogeneous background medium. I have employed a fitting of the experimental data to the diffusion model to accurately reconstruct not only the position and size, but also the optical properties including the relative index of refraction, absorption and scattering coefficients of objects immersed in highly scattering media. In this thesis I describe a model for locating and characterizing optical inhomogeneities in a turbid medium. I will go on to discuss limits of the technique and present data collected in vivo from a 55 year old female subject with a malignant breast cancer that was detected and optically characterized by these techniques.
Issue Date:1999
Description:82 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.
Other Identifier(s):(MiAaPQ)AAI9921750
Date Available in IDEALS:2015-09-25
Date Deposited:1999

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