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Title:Engineering of Nonviral Vectors for Gene Therapy
Author(s):Forrest, Marcus Laird
Doctoral Committee Chair(s):Pack, Daniel W.
Department / Program:Chemical and Biomolecular Engineering
Discipline:Chemical and Biomolecular Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Engineering, Biomedical
Abstract:Finally, for polymeric devices to be made safe and efficient for in vivo usage there must be some means to target them to specific cells or tissues. Various cyclodextrins were conjugated to PEI using an amide linkage. The hydrophobic interior of the cyclodextrin allows the facile addition of small targeting and lysomotropic agents to the polyplex without chemical conjugation. By applying a hydrophobic analog of human insulin to the cyclodextrin polyplexes, I was able demonstrate a 2--3 fold enhancement in transfection efficiency in insulin receptor-rich cell lines.
Issue Date:2003
Type:Text
Language:English
Description:150 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003.
URI:http://hdl.handle.net/2142/82352
Other Identifier(s):(MiAaPQ)AAI3101840
Date Available in IDEALS:2015-09-25
Date Deposited:2003


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