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Title:Laminar Flow-Based Microchemical Systems for Power Generation, Electrochemical Synthesis, and Biological Cell Studies
Author(s):Choban, Eric Raymond
Doctoral Committee Chair(s):Kenis, Paul J.A.
Department / Program:Chemical and Biomolecular Engineering
Discipline:Chemical and Biomolecular Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Engineering, Chemical
Abstract:Similarly in this thesis, multistream laminar flow is used in microfluidic systems for (1) biocatalytic synthesis of fine chemicals by microscale-enabled efficient regeneration of cofactors, as well as for (2) the study of intestinal stem cells on a surface that mimics their in vivo environment. In the first system, the ability to focus reagent streams close to the electrode wall results in a cofactor regeneration efficiency of over 30%. In the second system, microfluidic networks are used to create covalently immobilized surface gradients of extracellular matrix (ECM) proteins, laminin and collagen 1. These microfluidic platforms are capable of eliciting cell responses such as migration, proliferation, and differentiation, and offer the possibility of in vitro studies of a variety cell lines in response to different immobilized and soluble ECM components.
Issue Date:2004
Description:158 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.
Other Identifier(s):(MiAaPQ)AAI3160874
Date Available in IDEALS:2015-09-25
Date Deposited:2004

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