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Title:Homophilic and Heterophilic Interactions Among Cadherin Cell Adhesion Molecules
Author(s):Prakasam, Anil Kumar
Doctoral Committee Chair(s):Deborah Leckband
Department / Program:Chemical Engineering
Discipline:Chemical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Biophysics, General
Abstract:All three of the cadherins investigated in this thesis formed strong heterophilic bonds at three ectodomain alignments. Of the three, the inner bond (strongest) corresponding to full ectodomain overlap, did not exhibit much variation in either the homophilic or the heterophilic interactions. The two outer bonds (weaker) which are attributed to EC2/EC2 and EC1/EC1 binding, exhibit the greatest variation in bond strengths. In contrast to current thinking, these data show that there is no energetic preference for homophilic over heterophilic binding that would explain the cell sorting behavior.
Issue Date:2005
Description:144 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.
Other Identifier(s):(MiAaPQ)AAI3199117
Date Available in IDEALS:2015-09-25
Date Deposited:2005

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