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Title:Hybrid Gene Therapy Vectors Comprised of Synthetic Polymer and Noninfectious Virus -Like Particles
Author(s):Ramsey, Joshua
Doctoral Committee Chair(s):Pack, Daniel W.
Department / Program:Chemical Engineering
Discipline:Chemical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Engineering, Chemical
Abstract:While the hybrid vectors have combined some of the beneficial traits of the polymer and viral components the efficiency of the vector is low, in comparison to conventional viral vectors. Based on the changes in gene expression over time and the effect of chloroquine, the limiting step of hybrid vector cell transduction appears to be endolysosomal escape of the complex. The polymer component fails to mediate escape as efficiently as the MLV envelope protein, likely resulting in the degradation of internalized hybrid vector complexes. Incorporation of polymers better suited for mediating escape from the endolysosomal network could likely improve the hybrid vector efficiency.
Issue Date:2006
Description:171 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.
Other Identifier(s):(MiAaPQ)AAI3250313
Date Available in IDEALS:2015-09-25
Date Deposited:2006

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