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Title:Microblood Analyzers for the Sensitive and Portable Detection of Clinically Relevant Cardiac Markers
Author(s):Larsen, Robert T.
Doctoral Committee Chair(s):Masel, Richard I.
Department / Program:Chemical Engineering
Discipline:Chemical Engineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Engineering, Chemical
Abstract:A laminar tube flow with 1st order wall reaction model was used for the cFABP microdevice assay, which could predict assay behavior for a range of conditions. The pseudo-first order reaction rate was estimated at ∼1.5x10-6 m/s, and it was determined that a 40 mum wide channel operated in the desirable reaction rate limited regime, rather than the undesirable mass transfer limited regime of conventional heterogeneous immunoassays. The model also provided reasonable estimates of assay sensitivity (0.5 pg/mL--600 pg/mL depending on the assay parameters).
Issue Date:2007
Type:Text
Language:English
Description:177 p.
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.
URI:http://hdl.handle.net/2142/82403
Other Identifier(s):(MiAaPQ)AAI3290461
Date Available in IDEALS:2015-09-25
Date Deposited:2007


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